Evidenza Precision Medicine (Evidenza) Makes Finding, Reviewing and Reading The Latest Medical Evidence From Clinical Studies Accessible, Readable, and Relevant. Together With Its Partners In A.I., Evidenza Used This Technology on Behalf of Consumers and Physicians to Curate Data For Doctors. We Can Rapidly Search 27.3 Million Articles and 1.2 Milion Concepts from Published Sources Using Your PICO(T) Question(s). We Find Relevant and Specific Medical Literature To Help Physicians Make More Informed Decisions Based On Actual Medical Evidence and Fact. Powered by Natural Language Processing (NLP) and Artificial Intelligence (AI) Technology, Physicians Will Receive User-Friendly, Easy-to-Understand Summarized Reports. For Further Deep-Dives Into The Evidence, We Will Also Provide Physicians With The Meta-Analysis Results From Clinical Trials, RWE, and the literature, via Natural Language Processing technology in Our Partners AI platform. By Using This Reports, Physicians Can Provide Patients With The Evidence To Support Their Treatment Options, Rapid Review & Monitoring of Pubs, Trials, Conferences, & News. Accelerate your decision-making timelines with fast, accurate and data-supported intel.

Evidence is the highest level of truth regarding medical therapies. Evidence will enable you to see how many patients got a specific therapy and how many of these patients had a good or bad outcome. Using evidence from research studies is like entering a virtual waiting room of patients just like yourself, and asking, “What happened after undergoing your unique treatments?”

Physicians rely on medical evidence and the interpretation of medical studies and literature to make the most informed treatment decisions on behalf of their Patients. 

The Basics of Evidence

• Medical evidence is a form of expert evidence. Medical evidence can take many forms. It can include a doctor's clinical notes or records, and the forms a doctor completes and sends to WorkSafeBC on a regular basis.[1]
  
• Evidence Based Medicine (EBM) According to definition Evidence Based Medicine represents integration of clinical expertise, patient’s values and best available evidence in process of decision making related to patients health care.[2]
  
• Real-world Evidence is the clinical evidence regarding the usage and potential benefits or risks of a medical product derived from analysis of RWD. RWE can be generated by different study designs or analyses, including but not limited to, randomized trials, including large simple trials, pragmatic trials, and observational studies (prospective and/or retrospective). Real-world evidence makes use of data from populations that are better representative of real practice than those studied in clinical trials. Real-world evidence can help validate results observed in clinical trials or fill in knowledge gaps when trial data is lacking.
  

During the last decade, concept of Evidence Based Medicine (EBM) caused great interest among health professionals. Medical knowledge grows every day, so that previously accepted facts rapidly become old and it seems impossible to follow such explosion of scientific information. There are clear difficulties when clinician needs to keep step with the new achievements published in medical journals: for example, general practitioner should read 19 articles every day (1), and we know that many of them have only one hour per week for this.[2]

On average, physicians spend less than two minutes seeking an answer to a medical question.

The two most common sources physicians turn to are:

1. Fellow physicians, pharmacists and other individuals; and
2. Drug references and textbooks.[3]

One of the greatest achievements of evidence-based medicine has been the development of systematic reviews and meta-analyses, methods by which researchers identify multiple studies on a topic, separate the best ones and then critically analyze them to come up with a summary of the best available evidence.

The key difference between evidence-based medicine and traditional medicine is not that EBM considers the evidence while the latter does not. Both take evidence into account; however, EBM demands better evidence than has traditionally been used.

In Summary, What Is Medical Evidence, EBM and RWE?

Medical Evidence is everything that is used to reveal and determine the truth. Medical Evidence comprises medical knowledge, from clinical trials and published research to reveal the truth about medical conditions and the safest and most effective treatments. Medical Evidence is the highest level of truth regarding medical therapies. Medical Evidence will enable Physicians to see how many patients got a specific therapy and how many of these patients had a good or bad outcome.

• Enable specialists and/or generalists to use evidence to determine the most effective and safest therapy for any specific patient population.
  
• Use evidence to get coverage on recommended therapies or treatments
  
• Stay up-to-date on all published clinical studies
  
• Determine if practice management guidelines are valid and relevant

Even the FDA has weighed in on the topic recently stating "Real-world data (RWD) and Real-World Evidence (RWE) are playing an increasing role in health care decisions."[5] Using Medical evidence from research studies and published research is like entering a virtual waiting room of Patients just like yourself, and asking, “What happened after undergoing your unique treatments?” We look for evidence when we buy HDTVs, cars, computers, homes and stocks. Why not apply the same type of research and review to choose a medical therapy?

Sources

1. https://www.wcat.bc.ca/appeals/preparing/medical_evidence.html
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789163/
3 http://www.aafp.org/fpm/2004/0200/p51.html
4. https://www.usnews.com/education/blogs/medical-school-admissions-doctor/2012/08/27/medical-students-should-consider-evidence-based-medicine
5. https://www.fda.gov/science-research/science-and-research-special-topics/real-world-evidence

How It Works

1. Our initial interview process with each Physician enables our team to create a custom “framed” question(s) with you that matches your unique medical research need(s). Our evidence technologies and analysts will then be able to find and deliver evidence that answers your “framed” question(s).
2. Submit Your PICO Question (See Examples Below)
3. Please describe or leave any pertinent, non-HIPAA or non-patient identifiable information in the description if necessary to help us with your query. 
4. Choose A Payment Option
5. Upon Payment Confirmation, You'll Receive Verification of Receipt of Your PICO Question Submission and We'll Get To Work!
6. You should receive a one to two page Evidenza DOC REFERENCE Summary via email from us in 1 to 2 business days. Please note, Most PICO Reports, Medical Literature and Summaries Can Be Queried in 1-2 business days. Dependent upon the complexity and clarity of your PICO question, it may take longer in some cases. Thank you! 

WHAT IS CONTAINED IN THE SUMMARIES? EASY to READ FORMAT Sourced By Evidenza DOC REFERENCE STUDIES

Our standardized summary, depending upon complexity, is usually comprised of a one-page analysis based on one PICO Question at a time.

Each summary contains: 

• Your PICO Question
• Link(s) to Relevant Study(s)
• Summary (or Screen Shot) of Relevant Data Specific to Question
• Call to Action For Doctors (if Applicable)
  

EXAMPLES of SUMMARIES

• Client requested the efficacy of the Influenza Vaccine
  Out of 1,123 healthy people who received the Influenza vaccine, 41 of them (3%) were diagnosed with Influenza during the flu season, while out of 905 healthy people who did not receive the Influenza vaccine, 122 of them (13%) were diagnosed with Influenza during the flu season.
• Client requested evidence on the most effective therapy for Erectile Dysfunction
  Out of 288 patients who used the drug Sildenafil, 168 of them (58%) showed an improvement in erections, while out of 285 patients who used placebo, 37 of them (13%) showed an improvement in erections.
• Client requested evidence on the most evidence therapy for Pancreatic Cancer
  Out of 1,753 patients who took Erlotinib to treat their pancreatic cancer, 147 of them (8%) had disease response within 3 years, while out of 1,518 patients who took placebo, 73 (5%) of them had disease response within 3 years.
• Client requested evidence on the most effective therapy for Aortic Aneurysm Repair
  Out of 169,985 patients who underwent minimally invasive graft repair of an aortic aneurysm, 5,145 of them (3%) died within 10 years, while out of 394,317 patients who underwent open surgical repair of an aortic aneurysm, 43,102 of them (11%) died within 10 years.
• Client requested evidence on the most effective therapy for localized prostate cancer
  Out of 42,616 people who have localized prostate cancer and chose to have their prostate removed, 642 of them (1%) died due to prostate cancer within 20 years, while out of 23,401 people who have localized prostate cancer and chose no treatment or active surveillance, 1124 of them (4%) died due to prostate cancer within 20 years.
• Client requested evidence on the most effective therapy for Rheumatoid Arthritis
  The evidence shows that out of 764 patients who used a combinations of DMARDs, 102 of them (13%) experienced a flare-up within 26 weeks, while out of 657 patients who used a combination of placebo and DMARDs, 139 of them (21%) experienced a flare-up within 26 weeks.
• Client requested evidence on the safety of Hip Replacement surgery
  Out of 2,561 patients who underwent hip resurfacing, 211 of them (8%) needed revision surgery, while out of 173,364 patients who underwent total hip arthroplasty, 2,031 of them (1%) needed revision surgery
• Client requested evidence on the most effective therapy for Schizophrenia
  Out of 269 patients who took the drug Aripinprazole, 27 of them (10%) had a relapse of Schizophrenia within 1 year, while out of 134 patients who took placebo, 53 of them (39% ) had a relapse of Schizophrenia within 1 year.

Examples of PICO Questions and How To Frame Your Question:

• "What is the evidence the flu shot prevents influenza disease in healthy adults?"
• "What is the evidence that animal research leads to major positive medical discoveries in human healthcare?"
• "What is the evidence that Testosterone Treatment is safe in males over 40?"
• "Does hand washing among healthcare workers reduce hospital acquired infections?"
• "What do the clinical trials say about prescription drug treatment for the treatment of Prostate Cancer?"
• "What is the evidence that vaccines cause autism?"
• "What is the evidence for the best knee prosthesis (knee replacement) for patients with severe osteoarthritis?"
• "What is the effectiveness of continuous passive motion therapy (CPM therapy) following knee replacement in achieving optimal range of motion?"
• "What is the evidence that graft repair (vs open surgery) has better clinical outcomes (i.e.: rate of paraplegia) in patients undergoing aneurysm repair?"
• "What is the evidence that medicinal marijuana has any clinical benefits in different diseases (i.e.: multiple sclerosis)?"
• "What is the evidence for cell phones (or any source of electro-magnetic radiation) causing any medical problem (ie: memory loss, brain tumors, etc.)?"
• "What is the evidence that statins (cholesterol lowering medications) prevent heart attacks/strokes/death in patients with high cholesterol?"
• "What is the evidence that living near freeways causes lung disease?"
• "What is the evidence that treatment (i.e.: surgery vs radiation vs proton beam vs watchful waiting) for localized prostate cancer has different survival rates?"
• "I am looking for evidence-based articles on managing acute pain in sickle cell patients."
• "What does the Medical Evidence and Literature tell us about Ibuprofen side effects and/or safety for COVID-19 confirmed Patients?"
• "What Does The Medical Evidence and Literature Say About the Safety for Healthcare Professionals Using Cloth Fabric Materials as Protective Measures for Filtration and Protection from Common Particles and Viral Infections?"
• "Is the incidence of ventilator-associated-pneumonia decreased by a higher nurse-patient ratio?"
• "What is the effectiveness of restraints in reducing the occurrence of falls in patients 65 and over?"
• "Does exercising regularly during an inpatient hospitalization reduce weight gain among psychiatric patients?"

For a more in depth analytics or for multiple PICO Question(s) queries and summaries, we recommend you please send a message to info@evidenza.solutions to request more information.

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