Current or history of skin cancer, or pre-malignant moles Pregnancy or nursing Any active conditions in the treatment area, such as sores, eczema, rash, fragile skin, swollen, burnt or injured skin, active acne, rosacea, dermatitis, psoriasis, or active Herpes Simples Take precaution when treating over areas of active acne, avoid areas of severe active acne. When treating patients with predisposition to acne, occasional and transit acne eruptions may occur, which should be cared with acne treatment products Excessive fresh skin tan (within the last few days) Vascular disorders such as: telangiectasia, varicose veins, thrombosis, phlebitis in the applied area Severe concurrent disease such as: un-controlled diabetes, nervous diseases, cardiac disorder and cancer. In such cases, consult the treating physician In case of any aesthetic procedure performed recently on applied area such as mesotherapy, peeling, resurfacing or recent use of products such as Accutane or RetinA, consult the treating physician before using geneO+ Known allergies to cosmetics or other products, or experienced severe allergic reactions like hives