POZ Quiz: How Well Do You Know the History of HIV Treatment?

Test Your Knowledge of the History of HIV Treatment

Take this quiz on milestones in effective antiretroviral therapy in the United States.
1. When was the first HIV medication approved by the Food and Drug Administration (FDA)?

1985 1986 1987
Answer: Retrovir (zidovudine, or AZT) was approved in 1987.
2. In December 1995, the first protease inhibitor was approved. What was it?

Invirase Crixivan Lexiva
Answer: Developed by Roche, Invirase (saquinavir) was the sixth antiretroviral and first protease inhibitor approved by the FDA.
3. At the 11th International AIDS Conference, numerous studies demonstrated that triple-combination antiretroviral (ARV) treatment was effective. Where did this conference take place?

Geneva Berlin Vancouver
Answer: The breakthrough news was announced at the 11th International AIDS Conference, which took place in Vancouver in 1996.
4. What was the first fixed-dose combination HIV medication?

Juluca Combivir Epzicom
Answer: Combivir (zidovudine/lamivudine) was approved by the FDA in 1997 and greatly simplified HIV treatment at the time.
5. In 1998, the Department of Health and Human Services issued the first federal HIV treatment guidelines, which recommended treatment for those with fewer than how many CD4 cells?

100 200 500
Answer: HIV treatment was recommended for people with HIV with fewer than 500 CD4s. Today, the current guidelines recommend treatment for all people living with HIV regardless of CD4 count.
6. What was the first once-daily, single-table HIV regimen?

Atripla Complera Stribild
Answer: Atripla (efavirenz/tenofovir disoproxil fumarate/emtricitabine) was approved in 2006.
7. In 2011, which study found that taking ARVs reduces the risk of transmitting HIV through heterosexual sex by 96%?

HPTN 052 SMART REPRIEVE
Answer: In 2011, the HIV Prevention Trials Network (HPTN 052) study demonstrated that the use of ARVs by HIV-positive heterosexual men and women cut the chance that their HIV-negative partner would contract the virus by roughly 96%. HPTN 052 and other studies prove that people living with HIV on effective treatment do not sexually transmit the virus, which is known as U=U, or Undetectable Equals Untransmittable.
8. When was Truvada approved for use as pre-exposure prophylaxis (PrEP)?

2010 2011 2012
Answer: The FDA approved Truvada as a tool to prevent HIV in 2012.
9. What was the first approved complete, long-acting injectable HIV regimen?

Cabenuva Biktarvy Symtuza
Answer: Cabenuva (cabotegravir/rilpivirine) was approved in early 2021. It is administered every four weeks.
10. Which of the following is not used to boost other antiretrovirals?

Norvir Tybost Trogarzo
Answer: Trogarzo. Both Norvir and Tybost are used to boost the levels of other antiretrovirals in the blood.
Total Correct
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Test Your Knowledge of the History of HIV Treatment