This section helps you to better define the question of interest and consider the potential variations of this question (e.g. related to the population, to the intervention and comparators). When considering all its potential variations more than one relevant question could be identified. Developing that questions in a structured format (e.g. population, intervention, comparator, and outcome or PICO) will facilitate not only the evidence search but it will also help to identify which question is a priority for a “living evidence” approach.
To adequately complete the steps in this section, it is desirable to work it with content experts in the subject of interest (i.e. the panel in the context of GPC development or group of experts in the context of HTA)
If you have already worked on definition of the question of interest and its derived PICOs in line with your organisational methods or processes, you may skip Section A. If you have not done yet you may find it useful to follow this section guidance.