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  • Case 1.  61 y/o F presents with a 2-day history of nausea and vomiting. PMH: HTN, endometrial cancer s/p hysterectomy in 2010, heterozygous factor II mutation. Thrombosis history includes PE in 2007, DVTs over 20 years ago. Pt takes apixaban 5 mg BID at home.  

    Pt diagnosed with metastases to the liver and new bilateral segmental PEs. The patient needs to be taken for a liver biopsy. How will you manage anticoagulation? The antithrombosis pharmacy consulting team was asked to weigh in. 

    Things to think about regarding anticoagulation: bleed risk of procedure, when to hold and resume anticoagulation surrounding procedure. Risks vs Benefits?

    Anticoagulation was held pre-biopsy. The pt now is diagnosed with multiple cerebral infarcts. Will you restart anticoagulation? How? 

    Neurology ruled out concern for cerebral hemorrhagic conversion. The patient was given x1 dose UFH SQ 6 hours post-procedure. High-intensity UFH gtt started 12-hours post-biopsy without bolus. 

  • Case 2.  46 y/o M admitted for alcohol withdrawal to the ICU. Patient was admitted 2 weeks ago for UGIB. Thrombosis hx includes unprovoked PE in 2013. 

    During hospitalization, pt found to have right ulnar vein thrombosis and right basilic vein thrombosis. Should we anticoagulate this pt? The antithrombosis pharmacy consult team was asked to weigh in.

    Considerations: recent GI bleed and bleed risk? Location of thrombi? Provoking factor?

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