• Cyclarity Therapeutics Patient Questionnaire

  • Heart attacks and strokes, amongst other diseases, are usually caused by a process called “atherosclerosis”. This is the process by which our blood vessels (arteries) become clogged with fatty deposits, known as “plaques”. Plaque can reduce blood supply to affected organs, causing loss of function and sometimes pain. Chest pain (angina) is one example, due to limited blood supply to the heart. Eventually, blood supply to organs may be seriously disrupted, resulting in permanent damage, such as heart attacks or strokes.

    There are many medications now available that can slow down the progression of atherosclerosis. Some also lower the risk of heart attacks and strokes in people with atherosclerosis. Cyclarity therapeutics is looking at new technology designed to reverse the processes of plaques (hardened areas) forming in the blood vessels.

    We would be grateful if you could complete the following short questionnaire. This is aimed at patients with atherosclerosis and those close to them who may have been affected by knowing someone living with this disease. Please request more copies of the questionnaire if you need them. Your responses will be anonymous – we are not collecting details about who you are.

  • Have you experienced, or are you close to someone who has experienced, any of these conditions (select all that apply)
  • Was atherosclerosis (sometimes called plaque, “furring” or “clogging” of the arteries / blood vessels) involved? (select one)
  • Who was affected? (select one)
  • The affected person is … (select one)
  • The age of the person when they were first affected was … (select one)
  • The ethnic group of the affected person is … (select one)
  • Does the affected person have a family history of atherosclerotic disease (angina, heart attack, stroke, coronary artery disease, peripheral artery disease, carotid stenosis, etc.)? (select one)
  • How have the illnesses you selected above affected YOUR life? (select one)
  • 0/1000
  • Has the affected person used any of the following medicines for more than 6 months? (select all that apply)
  • How has the affected person’s use of these medicines changed YOUR life? (select one)
  • 0/1000
  • Are you satisfied with the current treatment options? (select one)
  • 0/1000
  • 0/1000
  • A treatment that could reverse atherosclerosis, reduce the risk of future events, and reduce the need for daily oral medication would be … (select one)
  • To get these benefits, it would be worth going to a clinic for an intravenous infusion of the drug … (select all that apply)
  • 0/1000

  • such as angiotensin-converting enzyme (ACE) inhibitors [e.g. enalapril, lisinopril, perindopril, ramipril], angiotensin receptor blockers (ARBs) [e.g. candesartan, irbesartan, losartan, valsartan, olmesartan], calcium channel blockers [e.g. amlodipine, felodipine, nifedipine], ‘water’ tablets / diuretics [e.g. indapamide, bendroflumethiazide], or beta-blockers [e.g. atenolol, bisoprolol].

  • e.g. aspirin, clopidogrel, prasugrel, ticagrelor

  • such as statins [e.g. atorvastatin, fluvastatin, pravastatin, rosuvastatin, simvastatin], cholesterol absorption inhibitors [e.g. ezetimibe], fibrates [e.g. bezafibrate, ciprofibrate, fenofibrate, gemfibrozil], PCSK9 inhibitors [e.g. evolocumab, alirocumab], or bile acid sequestrants [e.g. colestyramine, colestipol hydrochloride]

  • Taking part in a clinical trial to test whether this drug could help patients would be … (select one)
  • Should be Empty: