You selected the correct answer (C). In untreated people with HIV the half-life of plasma virus is approximately 20 minutes, and of productively infected CD4+ T-lymphocytes is approximately 24 hours. It is estimated that approximately 5% of plasma virus is produced from monocyte/macrophages in untreated patients. The second phase of decay is estimated to be 2-4 weeks.

Sorry, the correct answer is (C). In untreated people with HIV the half-life of plasma virus is approximately 20 minutes, and of productively infected CD4+ T-lymphocytes is approximately 24 hours. It is estimated that approximately 5% of plasma virus is produced from monocyte/macrophages in untreated patients. The second phase of decay is estimated to be 2-4 weeks.

You selected the correct answer (B). High level viral turnover results in selection for virtually every drug resistant mutation, even if they remain as a minority population until drug selection pressure is introduced. Similarly, once drug selection pressure is removed, wild type virus will generally predominate and resistant virus—while still present—may not be detected by resistance testing. The cellular reservoir appears to persist for more than a decade and the best evidence suggests that regardless of duration of viral suppression, viral rebound is likely to occur in the majority of individuals upon discontinuation of antiretroviral therapy.

Sorry, the correct answer is (B). High level viral turnover results in selection for virtually every drug resistant mutation, even if they remain as a minority population until drug selection pressure is introduced. Similarly, once drug selection pressure is removed, wild type virus will generally predominate and resistant virus—while still present—may not be detected by resistance testing. The cellular reservoir appears to persist for more than a decade and the best evidence suggests that regardless of duration of viral suppression, viral rebound is likely to occur in the majority of individuals upon discontinuation of antiretroviral therapy.

You selected the correct answer (D). Sterilizing cure is thought to have been achieved in select patients transplanted with CCR5 delta 32 homozygous donor cells, e.g. Berlin patient. There have been numerous cases of individuals who have maintained undetectable plasma HIV RNA in the absence of antiretroviral therapy, which may represent functional cure. It can be challenging to distinguish between sterilizing and functional cure in those without detectable virus despite being off antiretroviral therapy. Although there are several potential sites in which HIV may persist in the body of treated patients, the best characterized are the resting memory CD4+ T-lymphocytes that decay with a very long half-life.

Sorry the correct answer is (D). Sterilizing cure is thought to have been achieved in select patients transplanted with CCR5 delta 32 homozygous donor cells, e.g. Berlin patient. There have been numerous cases of individuals who have maintained undetectable plasma HIV RNA in the absence of antiretroviral therapy, which may represent functional cure. It can be challenging to distinguish between sterilizing and functional cure in those without detectable virus despite being off antiretroviral therapy. Although there are several potential sites in which HIV may persist in the body of treated patients, the best characterized are the resting memory CD4+ T-lymphocytes that decay with a very long half-life.

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