A 55 y.o. female with congestive heart failure (CHF), end stage renal disease (ESRD) due to diabetes mellitus (DM) and hypertension (HTN) s/p cadaver renal transplant (CRT) on Tacrolimus for immunosuppression presented to outside hospital (OSH) w/ acute dyspnea and productive cough with fever. After admission at OSH, the patient’s oxygen (O2) requirements increased, she became lethargic and an RRT was called with concern for sepsis. The patient was started on BIPAP due to O2 sats in the 90’s and transferred to KODE Hospital as a direct admit to ICU.
Upon admission to the ICU, she was intubated for acute respiratory failure with hypoxia. CT chest showed bilateral infiltrates and she was started on azithromycin and cefepime. Creatine was 2.4, baseline 1.7. She was seen by Nephrology for acute kidney injury and longstanding CKD stage 3 of transplanted kidney.
Bronchoscopy with bronchoalveolar lavage (BAL) and transbronchial forceps tissue biopsy were performed on the left upper lung lobe, which revealed early low-grade papillary carcinoma (CA).
She continued to need respiratory support and was maintained on the ventilator for 3 days when she was successfully weaned.
Discharge diagnoses: pneumonia likely gram-negative, left upper lobe papillary CA, mediastinal lymphadenopathy, acute hypoxic respiratory failure, acute kidney injury, CKD, immunodeficiency due to Tacrolimus.