DCCM Research Screener

Study Eligibility Screener for ACUTE ADMISSIONS

Do not use for elective admissions
Enter patient bedspace
Age or estimated age if unknown*
Admission Characteristics - Please select ALL that apply*

Admitted with Community Acquired Pneumonia or COVIDAdmitted with TraumaAdmitted with a non-penetrating Traumatic Brain Injury with plan to receive an ICP wireAdmitted with proven or suspected primary brain lesion such as stroke, intra-cerebral haemorrhage or hypoxic ischemic encephalopathyAdmitted with suspected or confirmed sepsisStaphylococcus Aureus BacteremiaIntubated and VentilatedNone of Above
You have indicated that your patient has been admitted with community acquired pneumonia or COVID, select all that apply:

Invasively VentilatedReceiving Non-Invasive Ventilation (CPAP or BIPAP)Receiving High flow nasal prongs with FiO2>0.4Receiving VasopressorNone of the above
You have indicated that your patient has been admitted with trauma, select all that apply:

Expected stay in ICU >48hrsHemoglobin >upper limit of normalGCS 3 AND fixed and dilated pupilsHistory of DVT or Thromboembolic eventTreatment with EPO in last 30 days (e.g. chronic renal failure)Expected to die within 24hrsSpinal Cord Injury
You have indicated that your patient has been admitted with confirmed or suspected sepsis, select all that apply:

Systolic BP below 90mmHg or MAP below 65mmHgReceived >1000ml BUT no more than 2000ml of IV fluid (including prehospital fluids but excluding drugs and flushes)Lactate >2mmol/LNone of the above
Click "Clear all questions button" at bottom of form to enter a new patient or reset the form
Your Patient is Potentially Eligible for The Studies Listed Below - Please check full inclusion and exclusion criteria and discuss enrolment with the responsible ICU consultant. For enquires or assistance with enrolment please contact the DCCM Research Team on EXT 23399 between the hours of 0800 and 2000 or if non-urgent please click the submit button below to notify via automatic email message.
REMAPCAP

Additional Inclusion and Exclusion criteria

Inclusion Criteria

# Admitted to ICU within 48 hours of hospital admission
# CAP by clinical and radiologic criteria

Exclusion Criteria

# Healthcare-associated pneumonia
# Imminent death and no commitment to full active treatment
# Prior enrollment in REMAP-CAP in the last 90 days
EPO-TRAUMA

Additional Inclusion and Exclusion Criteria

Inclusion Criteria
# < 24 hours since primary traumatic injury
# Have informed consent from a legal surrogate according to local law

Exclusion Criteria

# A chronic hypercoagulable disorder, including known malignancy
# Treatment with EPO in the last 30 days
# First dose of study drug unable to be given within 24 hours of primary injury
# Pregnancy or lactation or 3 months postpartum
# Known sensitivity to mammalian cell derived products
# Known contraindication to epoetin alfa
# End stage renal failure (receives chronic dialysis)
# Severe pre-existing physical or mental disability or severe co-morbidity that may interfere with the assessment of outcome
# The treating physician believes it is not in the best interest of the patient to be randomised to this trial
ARISE FLUIDS

Additional Exclusion Criteria

Exclusion Criteria
# Confirmed or suspected pregnancy
# Transferred from another acute care facility
# Hypotension suspected to be due to a non-sepsis cause
# More than 6 hours has elapsed since presentation to the ED or more than 2 hours has elapsed since last inclusion criterion has been met
# Treating clinician considers that one or both of the treatment regimens are not suitable for the patient or the study protocol cannot be delivered e.g. limitation of care, requirement for immediate surgery
# Death is considered imminent or inevitable
# Underlying disease that makes survival to 90 days unlikely
# Inability to follow patient up to day 90 e.g. unstable accommodation, overseas visitor
# Previously enrolled in this study
BONANZA

Additional Exclusion Criteria

# Contraindication to placement of ICP monitor (e.g. uncorrectable coagulopathy).
# Pregnancy
# Bilaterally absent pupillary response (in the absence of confounders)
# Refractory hypotension despite medical attention
# Refractory hypoxia despite medical attention
# Non-survivable injury in view of treating clinician
# Known inability to perform ADLs without assistance prior to injury.
# 12 hours has elapsed since time of injury.
# CNS disease that is likely to impair accurate PbtO2 measurements (prior TBI, SAH, or
neoplasm).

# Only 1 patient in the unit can participate at any time

# Co-enrollment in MEGA-ROX is NOT possible

If after 5pm inclusion is only possible if Dr Jason Correia or Dr Chien Kow are oncall - pleased confirm with Neurosurgical registrar
MEGA-ROX or LOGICAL (if Out of Hospital Cardiac Arresst)

Additional Inclusion and Exclusion Criteria

Inclusion Criteria

# Must be enrolled within 12 h of fulfilling the eligibility criteria.

Exclusion Criteria

# Patients where either of the oxygen regimens being tested are considered clinically indicated or contraindicated

# Death is deemed imminent and inevitable

# Previously enrolled in the study

# CO-enrollment in the BONANZA Study is NOT possible

Enrollment may be undertaken by bedside nurse
SPICE IV

Additional Inclusion and Exclusion Criteria

Inclusion Criteria

# The treating clinicians believe that the patient will remain intubated and ventilated until the day after tomorrow (unlikely to be extubated next day)
# The patient requires immediate ongoing sedative medication for comfort, safety and to facilitate the delivery of life support measures.

Exclusion Criteria

# Has been intubated (excluding time spent intubated within an operating theatre or transport) for greater than 12 hours in an intensive care unit
# Proven or suspected spinal cord injury or other pathology that may result in permanent or prolonged weakness
# Admission with a suspected or proven drug overdose or burns.
# Administration of ongoing neuromuscular blockade
# Mean arterial blood (MAP) pressure that is less than 50 mmHg despite adequate resuscitation and vasopressor therapy at time of randomization
# Heart rate less than 55 beats per minute unless the patient is being treated with a betablocker or a high grade atrio-ventricular block in the absence of a functioning pacemaker
# Known sensitivity to dexmedetomidine
# Acute fulminant hepatic failure
# Receiving full time residential nursing care
# Death is deemed to be imminent or inevitable during this admission and either the attending physician, patient or substitute decision maker is not committed to active treatment
# Patient has an underlying disease that makes survival to 90 days unlikely
# Previously enrolled in the SPICE IV study
SNAP

Additional Inclusion and Exclusion Criteria

Discuss with the research team
Based on the information provided your patient is not CURRENTLY eligible for any of the current studies. Please reconsider eligibilty if the clinical scenario changes or discuss with the DCCM Research Team if you think this is incorrect
To receive the traditional chocolate reward please insert your name or initials prior to clicking the submit button to notify the research team by automatic email

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Study Eligibility Screener for ACUTE ADMISSIONS