The use of psilocybin can lead to transient adverse physical effects. The higher the dose, the more common and intense the effect. Additionally, the effects can vary depending on a person's genetic background, the use of certain medications, and the presence of certain physical conditions.
Cardiovascular: Psilocybin can cause transient increases in your heart rate and blood pressure. Psilocybin can cause adverse changes in your heart rhythm. Using psilocybin can be dangerous to people with cardiovascular conditions.
Gastrointestinal: Psilocybin can cause transient nausea, vomiting, diarrhea and other GI upset.
Hepatic: Psilocybin is broken down to its active ingredient in the liver. Taking psilocybin in the presence of liver impairment can be dangerous and influence the duration and intensity of the effects.
Renal: Psilocybin is eliminated from the body by your kidneys. The ingestions of psilocybin in the presence of kidney diesease can be dangerous and result in injury.