Thank you for your interest in the rareSHIFT Patient Group Repurposing Program, powered by Unravel Biosciences. This program generates RNA profiles for 20 or more patients and 20 or more healthy relative controls using non-invasive nasal swabs. The data are analyzed using Unravel Biosciences' BioNAV computational platform to identify patient stratification groups, each with specific therapeutic mechanisms and a list of potential drug hits. All data and a BioNAV analysis report are provided to you for research use. This study typically takes 3 months, with timelines mostly driven by participant responsiveness.
Please note that this research service is primarily aimed at foundations aiming to derstand the heterogeneity of their patient community and use the data to guide repurposing and new drug discovery programs.
Key steps:
- Register using this form to be provided with a link to a service agreement.
- Complete service agreement and submit deposit payment ($33,250).
- You will be provided with a customized email with instructions you can forward to your community for them to self-enroll confidentially, including consent and registration forms to collect additional information.
- Participants will receive sample collection kits, collect duplicate samples following provided instructions, and return samples using the prepaid return envelope. Shipping is via FedEx.
- Once all are received, patients' samples are RNA sequenced
- Data are analyzed by Unravel Biosciences
- You receive gene expression data for the patient and matching control, and a technical report and lay summary of the findings, including in silico drug repurposing hits for one or more patient subgroups.
- Pay balance ($33,250).
- Unravel team members are available throughout the process to answer any questions you may have and to discuss potential additional research studies you may wish to pursue.