SCNA24

Update on Advanced Anti-CD20 Therapeutics to Improve Outcomes for Patients with Multiple Sclerosis

Saturday, September 21st, 2024 from 7:30am – 8:30am EDT
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a. Hepatitis B surface antigen and hepatitis B core antibodyb. Complete blood countc. Cholesterol panel and hemoglobin A1cd. Transaminases/liver function tests
a. Results demonstrated a decrease in thalamic volume lossb. A decrease in MS activity was not reflected by multiple biomarkersc. Results demonstrated a decrease in MS Pathway Scoresd. Results demonstrated a decrease in MS Activity Scores
3. Your next clinic patient is a 35-year-old man who presents with a new diagnosis of multiple sclerosis. He is concerned about his increased risk for disability in the future and has researched different treatments options online but is unsure of which one to choose. With all other conditions and factors being equal, along without consideration of side effects, which of the following are considered to be high efficacy medications?*

a. Interferon betab. Alemtuzumabc. Teriflunomided. Anti-CD20 monoclonal antibodiese. Both B and D
a. There is no effect on peripheral B-cells with anti-CD20 therapeutics.b. B-cells are not affected by anti-CD 20 therapeutics.c. If peripheral B-cells are targeted, the B-cells in the CNS may not need to be targeted.d. Ongoing treatment with an anti-CD 20 therapeutic does not affect B-cell depletion in the periphery.
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Review recent efficacy and safety data for anti-CD20 therapeutics to treat patients with multiple sclerosis
Recognize the current unmet needs of patients with MS and the role of anti-CD20 therapeutics to improve outcomes for these patients

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Sandip Jain, MD

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