I, the undersigned patient or legal guardian, hereby acknowledge that I have read and understood the disclosure, terms, and conditions provided below, and I consent to the medical care and procedures outlined by Dr. Peter Eng and other doctors from Dr Eng Medical Centre and WillowVale Clinic.
In some situations, we may prescribe off-label use of certain medications as an adjunct to standard-of-care cancer treatments. For eg. medications, such as Metformin and Atorvastatin, etc., which are typically used by GPs for managing diabetes or high cholesterol, have shown effects on inhibiting the metabolism of cancer cells in lab studies. Although randomized controlled clinical trial data may still be lacking, these medications have been used in general practice for decades and have well-known safety profiles and potential side effects, which will be discussed with the patient during the consult. Regular monitoring and follow-up appointments will be scheduled to assess the patient's response and adjust the treatment plan if necessary.
The Repurposing Drugs in Oncology (ReDO) protocol consists of 19 medications and nutrients, which are introduced one by one, 3 days apart, and side effects monitored over a period of 2 months. You may need to take some of these, or all of it as part of your treatment.
Each medication and supplement in the ReDO protocol will be introduced one at a time with 3-4 days space in between, so that monitor any side effects, such as nausea, vomiting, drop in blood pressure, increased pain, anxiety, low blood sugar, fatigue, bleeding or bruising. Please get in touch with the clinic immediately, if you notice any side effects. See also Table titled ‘ReDO protocol dosages, side effects, cautions’
How are the 19 items of the ReDO protocol introduced and side effects monitored?
Note: Implementation of the full ReDO protocol will take 2 months. Start the ReDO protocol consisting of 19 items, one item at a time, add each item every 3 days monitoring side effects. Communicate any side effects with the clinic nurse or doctor.
Side effects reported by patients on the ReDO protocol in Dr Binjemain’s practice were mainly nausea and vomiting, and/or fatigue.
Side effects: Nausea / Vomiting – Next steps:
If nausea/vomiting occurs – stop everything for 1-2 days. Report on the clinic app / inform the nurse.
If not better after pausing for 1-2 days, consult with a nurse or doctor and apply anti-nausea medication, e.g. Maxolon (Metoclopramide), Zofran (Ondansetron), IVC, and IV glutathione until better.
If better – restart from the point protocol stopped.
If start to feel nausea/vomit again on restarting, then reduce the dose of the introduced meds.
If ok, continue.
Most of the nausea/vomiting is due to tumour lysis ie dead cancer cells, meaning the treatment is working. As tumour lysis can lead to renal impairment, we will monitor the patient routinely for abnormal uric acid levels and abnormal eGFR levels.
Side effects: Fatigue
In case of debilitating fatigue, the patient is advised to take a break from the ReDO protocol, until feeling better, usually after 3 days the patient can resume on a lower dose regime, as discussed with the doctor.
Dosing is very patient-dependent.
Other unexpected side effects:
If you experience a drop in blood pressure, increased pain, anxiety, low blood sugar, bleeding or bruising, get in touch with the clinic immediately.
The evidence on why we use these medications in supporting cancer patients is provided as references below.
