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Assisted hatching is a laboratory procedure that is sometimes done along with in vitro fertilization (IVF) treatment. IVF involves mixing eggs with sperm in a laboratory to fertilize them. The fertilized eggs develop into embryos. The best embryo can then be placed into the woman’s uterus in the hopes that she will become pregnant.
For the first 5 to 7 days of development, the embryo is surrounded by cells that make up a protective shell, called the zona pellucida. Normally, when the embryo reaches the uterus, this zona partially dissolves and the embryo ‘hatches’ out, allowing it to implant in the uterus.
In some women, infertility may be caused by a hardening of the zona, which makes it difficult for the embryo to hatch and implant. During assisted hatching, the zona pellucida is thinned or ruptured to enable the embryo to emerge and implant.
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The embryologist uses a micro-needle to puncture through the zona pellucida, go just underneath the shell, and then come out the other end. The area between the two punctures is then gently abraded until a small tear occurs. With this method, however, it is difficult to control the size of the opening.
What are the success rates of Assisted Hatching?
Assisted hatching has been proven to have a fairly high success rate, especially when performed by a skilled expert. Pregnancy rates are approximately 49% in patients between the ages of 35 and 39. Women who are over the age of 40 are typically proven to have lower success rates, but assisted hatching still provides them with a better opportunity for conception than IVF which is performed without this procedure.