Shortening the patient journey - Module 2 (post-knowledge check)

What is the primary goal of using immunosuppressants like azathioprine in the management of IBD?*

Immediate symptom reliefInducing remission and reducing reliance on corticosteroidsHealing mucosal damagePreventing surgery

In patients with IBD who are refractory to multiple therapies, what is a recommended approach to consider?*

Immediate surgery without further medication adjustmentsSwitching to a different class of medicationIncreasing the dose of the current medication onlyDiscontinuing all medications and starting from scratch

Which of the following immunomodulators is most commonly associated with macrophage activation syndrome (MAS)?*

MethotrexateThiopurinesTacrolimusCyclosporine

In patients treated with thiopurines (azathioprine or 6-mercaptopurine) for IBD, which of the following laboratory tests is crucial to monitor due to the risk of severe side effects?*

Liver function tests (LFTs)Complete blood count (CBC) with differentialSerum creatinine levelsLipid profile

What is a significant potential adverse effect of using cyclosporine in patients with severe ulcerative colitis?*

Renal toxicityCardiac arrhythmiasPeripheral neuropathyPulmonary fibrosis

Which of the following tests is recommended to monitor for potential adverse effects of methotrexate therapy in IBD patients?*

Serum potassium levelsLiver function tests (LFTs)Serum magnesium levelsB-type natriuretic peptide (BNP)

Which biologic agent targets integrins and is used specifically for the treatment of moderate to severe ulcerative colitis?*

VedolizumabUstekinumabNatalizumabCertolizumab pegol

In patients receiving biologics for IBD, which screening test is particularly important to perform prior to initiation of therapy due to the risk of reactivation?*

Tuberculosis (TB) screeningHepatitis C screeningHuman Immunodeficiency Virus (HIV) testingEpstein-Barr Virus (EBV) testing

Which of the following is a common side effect associated with the use of anti-TNF-α biologics like infliximab*

Cytomegalovirus infectionHyperglycemiaHyperlipidemiaHypothyroidism

When considering dose adjustments for tofacitinib in the treatment of ulcerative colitis, which of the following factors is NOT typically considered?*

Disease severityComorbiditiesPrevious biological exposurePatient’s weight

What is a key factor in determining whether a patient with ulcerative colitis is a good candidate for dose reduction of tofacitinib?*

Low biomarker levelsEndoscopic subscoreSerum albumin levelsGenetic markers for IBD

Which antibiotic is often used in the treatment of perianal disease associated with Crohn's disease due to its efficacy in managing bacterial overgrowth and abscesses?*

MetronidazoleCiprofloxacinVancomycinDoxycycline

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Post-knowledge check