Integration Note (part 2)

Please answer the following questionnaires as best you're able. Once you hit submit, you'll be taken to the final integration questionnaire.
HRS (Version 4) is a list of statements referring to effects of the medicine you received. For each statement, please mark the answer that corresponds to the most intensely you experienced that effect during your session.

Please mark only one answer for each item; mark the one that seems best, even if none matches your experience exactly. For example, "Visual effects," if you experienced extremely intense visual effects during the time period specified, mark "Extremely." Do not worry if your answers to some questions are opposite to others. If two opposite experiences occurred at some point during the time period, answer each one according to what you experienced.
First Name
Date of birth

MonthDayYear
2 digit month, 2 digit day, 4 digit yearDate
Date of medicine journey

MonthDayYear
2 digit month, 2 digit day, 4 digit yearDate
Medicine & Route of Administration
(for example, ketamine, sublingual ; ketamine, iv)
Dose
Session Number
1. Amount of time between when the drug was administered and feeling an effect
2. A "rush"

1

2

3

4

5

1 is Not at All, 5 is Extremely
2a. Where was this rush located in your body?
3. Change in salivation

1

2

3

4

5

1 is Not at All, 5 is Extremely
3a. Was your mouth drier, wetter or both?
4. Body feels different

1

2

3

4

5

1 is Not at All, 5 is Extremely
4a. Please describe
5. Changes in sense of body weight

1

2

3

4

5

1 is Not at All, 5 is Extremely
5a. Was your body lighter, heavier or both?
6. Feel as if moving/falling through space

1

2

3

4

5

1 is Not at All, 5 is Extremely
7. Change in body temperature

1

2

3

4

5

1 is Not at All, 5 is Extremely
7a. Did you feel warmer, cooler, or both?
8. Electric/tingling feeling

1

2

3

4

5

1 is Not at All, 5 is Extremely
9. Pressure or weight in chest or abdomen

1

2

3

4

5

1 is Not at All, 5 is Extremely
9a. Physically loose, limber or flexible?

1

2

3

4

5

1 is Not at All, 5 is Extremely
10. Shaky feelings inside?

1

2

3

4

5

1 is Not at All, 5 is Extremely
11. Body shake/ tremble on the outside

1

2

3

4

5

1 is Not at All, 5 is Extremely
12. Feeling heart beating

1

2

3

4

5

1 is Not at All, 5 is Extremely
13. Heart skipping beats

1

2

3

4

5

1 is Not at All, 5 is Extremely
14. Nausea

1

2

3

4

5

1 is Not at All, 5 is Extremely
15. Physically comfortable

1

2

3

4

5

1 is Not at All, 5 is Extremely
16. Physically restless

1

2

3

4

5

1 is Not at All, 5 is Extremely
17. Flushed

1

2

3

4

5

1 is Not at All, 5 is Extremely
18. Urge to urinate

1

2

3

4

5

1 is Not at All, 5 is Extremely
19. Urge to move bowels

1

2

3

4

5

1 is Not at All, 5 is Extremely
20. Sexual Feelings

1

2

3

4

5

1 is Not at All, 5 is Extremely
21. Feel removed, detached, separated from body / did you lose awareness of your body?

1

2

3

4

5

1 is Not at All, 5 is Extremely
22. Change in skin's sensitivity

1

2

3

4

5

1 is Not at All, 5 is Extremely
22a. Was your skin more sensitive, less senstive, or both?
23. Sweating

1

2

3

4

5

1 is Not at All, 5 is Extremely
24. Headache

1

2

3

4

5

1 is Not at All, 5 is Extremely
25. Anxious

1

2

3

4

5

1 is Not at All, 5 is Extremely
26. Frightened

1

2

3

4

5

1 is Not at All, 5 is Extremely
27. Panic

1

2

3

4

5

1 is Not at All, 5 is Extremely
27a. Self-Accepting / Forgiving

1

2

3

4

5

1 is Not at All, 5 is Extremely
27b. Accepting / Forgiving of others

1

2

3

4

5

1 is Not at All, 5 is Extremely
28. At ease

1

2

3

4

5

1 is Not at All, 5 is Extremely
29. Feel like laughing

1

2

3

4

5

1 is Not at All, 5 is Extremely
30. Excited

1

2

3

4

5

1 is Not at All, 5 is Extremely
31. Awe, amazement

1

2

3

4

5

1 is Not at All, 5 is Extremely
31a. Understanding of others' feelings

1

2

3

4

5

1 is Not at All, 5 is Extremely
32. Safe

1

2

3

4

5

1 is Not at All, 5 is Extremely
33. Perceive presence of an other being

1

2

3

4

5

1 is Not at All, 5 is Extremely
33a. Please describe it briefly
33b. For example did it seem benevolent hostile or uninterested
33c. Did you interact with this other being
33d. Please briefly describe how you interacted with it
34. Change in feelings about sounds around you

1

2

3

4

5

1 is Not at All, 5 is Extremely
35. Happy

1

2

3

4

5

1 is Not at All, 5 is Extremely
36. Sad

1

2

3

4

5

1 is Not at All, 5 is Extremely
36a. Loving

1

2

3

4

5

1 is Not at All, 5 is Extremely
37. Euphoria

1

2

3

4

5

1 is Not at All, 5 is Extremely
38. Despair

1

2

3

4

5

1 is Not at All, 5 is Extremely
39. Feel like crying

1

2

3

4

5

1 is Not at All, 5 is Extremely
40. Change in closeness to people that were with you

1

2

3

4

5

1 is Not at All, 5 is Extremely
40a. Did you feel less close to them, more close, or both?
41. Change in "amount" of emotions

1

2

3

4

5

1 is Not at All, 5 is Extremely
41a. Did you feel less emotional, more emotional, or both?
42. Emotions seem different than usual

1

2

3

4

5

1 is Not at All, 5 is Extremely
43. Feelings of oneness with the universe

1

2

3

4

5

1 is Not at All, 5 is Extremely
44. Feel isolated from people and things

1

2

3

4

5

1 is Not at All, 5 is Extremely
45. Feel reborn

1

2

3

4

5

1 is Not at All, 5 is Extremely
46. Satisfaction with the experience

1

2

3

4

5

1 is Not at All, 5 is Extremely
47. Like the experience

1

2

3

4

5

1 is Not at All, 5 is Extremely
48. How soon would you like to repeat the experience?

1

2

3

4

5

1 is Never again, 5 is As soon as possible
49. Is this an experience you would like to have regularly?

1

2

3

4

5

1 is Not at All, 5 is Extremely
50. An odor

1

2

3

4

5

1 is Not at All, 5 is Extremely
51. A taste

1

2

3

4

5

1 is Not at All, 5 is Extremely
52. Hearing a sound or a voice within the experience

1

2

3

4

5

1 is Not at All, 5 is Extremely
53. Sense of silence or deep quiet

1

2

3

4

5

1 is Not at All, 5 is Extremely
54. Sounds in room sound different

1

2

3

4

5

1 is Not at All, 5 is Extremely
55. Difference in distinctiveness of sounds

1

2

3

4

5

1 is Not at All, 5 is Extremely
55a. Less distinct, more distinct, or both?
56. Auditory synesthesia (seeing sounds)

1

2

3

4

5

1 is Not at All, 5 is Extremely
57. Visual Effects

1

2

3

4

5

1 is Not at All, 5 is Extremely
58. Room looked different

1

2

3

4

5

1 is Not at All, 5 is Extremely
59. Changes in brightness of colors/objects

1

2

3

4

5

1 is Not at All, 5 is Extremely
59a. Were objects brighter, duller, or both?
60. Change in acuity of vision / visual distinctiveness of objects

1

2

3

4

5

1 is Not at All, 5 is Extremely
60a. Were objects sharper, blurrier, or both?
61. Visual field overlaid by patterns

1

2

3

4

5

1 is Not at All, 5 is Extremely
62. Vibration, jiggling, or other motion in the visual field

1

2

3

4

5

1 is Not at All, 5 is Extremely
63. Visual synesthesia (seeing tastes or seeing sounds)

1

2

3

4

5

1 is Not at All, 5 is Extremely
64. Visual images, visions, or hallucinations

1

2

3

4

5

1 is Not at All, 5 is Extremely
65. Kaleidoscopic nature of images/visions/hallucinations

1

2

3

4

5

1 is Not at All, 5 is Extremely
66. Difference in brightness of visions compared to usual daylight vision

1

2

3

4

5

1 is Not at All, 5 is Extremely
66a. Brighter, duller, or both
66b What were the predominant colors
67. Dimensionality of images/visions/hallucinations
68. Movement within visions/hallucinations

1

2

3

4

5

1 is Not at All, 5 is Extremely
69. White light

1

2

3

4

5

1 is Not at All, 5 is Extremely
70. Dead or dying

1

2

3

4

5

1 is Not at All, 5 is Extremely
71. Sense of speed

1

2

3

4

5

1 is Not at All, 5 is Extremely
72. Deja-vu (seen before)

1

2

3

4

5

1 is Not at All, 5 is Extremely
73. Jamais vu (never seen before)

1

2

3

4

5

1 is Not at All, 5 is Extremely
74. Contradictory feelings at the same time

1

2

3

4

5

1 is Not at All, 5 is Extremely
75. Sense of chaos

1

2

3

4

5

1 is Not at All, 5 is Extremely
76. Change in strength of sense of self

1

2

3

4

5

1 is Not at All, 5 is Extremely
76a. Was your sense of self stronger, weaker, or both?
77. New Thoughts or insights

1

2

3

4

5

1 is Not at All, 5 is Extremely
78. Thoughts of childhood

1

2

3

4

5

1 is Not at All, 5 is Extremely
79. Feel like a child

1

2

3

4

5

1 is Not at All, 5 is Extremely
80. Change in rate of thinking

1

2

3

4

5

1 is Not at All, 5 is Extremely
80a. Was your thinking faster, slower, or both?
81. Change in quality of thinking

1

2

3

4

5

1 is Not at All, 5 is Extremely
81a. Was your thinking sharper, duller, or both?
82. Difference in feeling of reality of experiences compared to every day experiences?

1

2

3

4

5

1 is Not at All, 5 is Extremely
82a. Did the experience seem more real, less real, or both?
83. Dreamlike nature of experience

1

2

3

4

5

1 is Not at All, 5 is Extremely
84. Thoughts of present or recent past

1

2

3

4

5

1 is Not at All, 5 is Extremely
85. Insights into personal or occupational concerns

1

2

3

4

5

1 is Not at All, 5 is Extremely
86. Change of rates of time passing

1

2

3

4

5

1 is Not at All, 5 is Extremely
86a. Was time passing faster, slower or both?
87. Unconscious

1

2

3

4

5

1 is Not at All, 5 is Extremely
88. Change in sense of reality

1

2

3

4

5

1 is Not at All, 5 is Extremely
88a. Did you feel more sane, less sane or both?
89. Urge to close your eyes

1

2

3

4

5

1 is Not at All, 5 is Extremely
90. Change in effort of breathing

1

2

3

4

5

1 is Not at All, 5 is Extremely
90a. Was your breathing more relaxed, more difficult, or both?
91. Able to follow the sequence of events

1

2

3

4

5

1 is Not at All, 5 is Extremely
92. Able to "let go"

1

2

3

4

5

1 is Not at All, 5 is Extremely
93. Able to focus attention

1

2

3

4

5

1 is Not at All, 5 is Extremely
94. In control

1

2

3

4

5

1 is Not at All, 5 is Extremely
95. Able to move around if asked to

1

2

3

4

5

1 is Not at All, 5 is Extremely
96. Could you remind yourself of where you were, that you have taken a medicine, and that the experience would be over at some point?

1

2

3

4

5

1 is Not at All, 5 is Extremely
97. Waxing and waning of the experience

1

2

3

4

5

1 is Not at All, 5 is Extremely
98. Intensity

1

2

3

4

5

1 is Not at All, 5 is Extremely
99. High

1

2

3

4

5

1 is Not at All, 5 is Extremely
100. Dose

1

2

3

4

5

1 is Microdose, 5 is Highest dose
101. I had no thoughts

1

2

3

4

5

1 is Not at all, 5 is Extremely
102. Feeling peaceful

1

2

3

4

5

1 is Not at all, 5 is Extremely
103. Sense of experiencing "more" than everyday experience

1

2

3

4

5

1 is Not at all, 5 is Extremely
104. Inanimate objects seemed alive

1

2

3

4

5

1 is Not at all, 5 is Extremely
105. Feeling exhausted

1

2

3

4

5

1 is Not at all, 5 is Extremely
106. Feeling stimulated

1

2

3

4

5

1 is Not at all, 5 is Extremely
107. Sense of meaningfulness

1

2

3

4

5

1 is Not at all, 5 is Extremely
108. Experience of beauty

1

2

3

4

5

1 is Not at all, 5 is Extremely
109. Feeling free

1

2

3

4

5

1 is Not at all, 5 is Extremely
110. Feeling confused or disoriented

1

2

3

4

5

1 is Not at all, 5 is Extremely
Any other comments?
HRS (Version 4) - Scoring Instructions

Below are instructions for scoring the HRS based on the 8-factor model (Calder et al., 2024 Instructions for scoring the original clinical clusters (Strassman et al., 1994) are also included for completeness.

1. Data entry and reverse scoring Most numerical questions are entered as "0" for "Not at all," and "4" for "Extremely." There are exceptions: #48: "Never again" is scored "0," while "As soon as possible" is scored "4." #67: "Not applicable" is scored as a missing value. "Linear" is scored as "0," "Flat/planar" is scored as "1, "and so on up to "Beyond dimensionality" as "4." The following items are reverse scored: 32, 91, 92, 93, 94, 95, 96 Note: There are several questions which we've not yet placed into factors. There are for possible inclusion in future versions of the HRS. Please enter them nevertheless.

2. Factor scores (8-factor model)

Factors scores are calculated using the mean score of all items within that factor.

Factor Vision Meaningfulness Euphoria Dysphoria Auditory and Minor Senses Liking Somaesthesia Volition

Items 2, 4-6, 21, 57-62, 64-68, 71, 80, 82, 83, 86, 98, 99 27a, 27b, 31a, 33, 36, 36a, 39-41, 43, 45, 53, 74, 76-79, 81, 84, 85 20, 29-31, 35, 37, 42 25-27, 38, 44, 70, 75, 87, 88 22, 34, 50, 52, 54, 55, 63 15, 28, 46-49 3, 8-13, 16, 90 32, 91-96

3. Clinical clusters (optional) Scores for the original six clinical clusters are calculated using the mean score of all items within each cluster:

Cluster Intensity Somaesthesia Affect Perception Cognition Volition

Items 97-99 2-11, 16, 20, 21 25, 26, 29-33, 37, 40-45, 47-49 17, 22, 52, 54, 55, 57-62, 64-69 71, 74, 75-77, 80-83, 85, 86, 88 89-96

Literature Calder AE, Qualls CR, Hasler G, et al. (2024) The Hallucinogen Rating Scale: Updated factor structure in a large, multi-study sample. Strassman RJ, Qualls CR, Uhlenhuth EH, et al. (1994) Dose-response study of N,N-dimethyltryptamine in humans. II. Subjective effects and preliminary results of a new rating scale. Arch Gen Psychiatry 51(2): 98-108.
Copyright© 1994-2024, by Rick J. Strassman, M.D., Department of Psychiatry, University of New Mexico, School of Medicine, Albuquerque, NM. All rights reserved.
MEQ 4 & CEQ 7

The Mystical Experience Questionnaire & Challenging Experience Questionnaire
Looking back on the entirety of your experience, please rate the degree to which at any time you experienced the following phenomena. Answer each question according to your feelings, thoughts, and experiences at the time of the session. In making each of your ratings, use the following scale:

0-None/Not at all
1-So slight cannot decide
2-Slight
3-Moderate
4-Strong (equivalent in degree to any other strong experience)
5-Extreme (more than any other time in my life and stronger than "strong")
1. Sense of Oneness, insight into ultimate reality, or sacredness

0

1

2

3

4

5

0 is Not at all, 5 is Extremely
2. Positive Mood

0

1

2

3

4

5

0 is Not at all, 5 is Extremely
3. Transcendence of Time and Space

0

1

2

3

4

5

0 is Not at all, 5 is Extremely
4. Ineffability (i.e., incapable of being expressed or described in words)

0

1

2

3

4

5

0 is Not at all, 5 is Extremely
Looking back on the entirety of your experience, please rate the degree to which at any time you experienced the following phenomena. Answer each question according to your feelings, thoughts, and experiences at the time of the session. In making each of your ratings, use the following scale:

0-None/Not at all
1-So slight cannot decide
2-Slight
3-Moderate
4-Strong (equivalent in degree to any other strong experience)
5-Extreme (more than any other time in my life and stronger than "strong")
1. Fear

0

1

2

3

4

5

0 is Not at all, 5 is Extremely
2. Grief

0

1

2

3

4

5

0 is Not at all, 5 is Extremely
3. Physical Distress

0

1

2

3

4

5

0 is Not at all, 5 is Extremely
4. Insanity

0

1

2

3

4

5

0 is Not at all, 5 is Extremely
5. Isolation

0

1

2

3

4

5

0 is Not at all, 5 is Extremely
6. Thoughts or feelings of death

0

1

2

3

4

5

0 is Not at all, 5 is Extremely
7. Paranoia

0

1

2

3

4

5

0 is Not at all, 5 is Extremely
Should be Empty:

MEQ 4 & CEQ 7