At the end of the session, the learner will be able to:
1. Describe the clinical rationale, safety profile, and trial design for investigating single-dose psilocybin as a treatment for obsessive-compulsive disorder (OCD), with emphasis on its implementation in a randomized, double-blind, placebo-controlled study and the underlying theoretical model of action.
2. Identify key psychological and neurobiological mechanisms of therapeutic change following psilocybin administration in individuals with treatment-resistant OCD, and evaluate how subjective psychedelic experiences relate to symptom improvement.