Answer: B – Tafamidis. Tafamidis is a ‘stabilizer’, meaning it stabilizes the normal circulating form of TTR, thus making deposition as amyloid fibrils less likely. Vutrisiran, Nex-z, and nucresiran all work by lowering the liver’s production of TTR, though to date the only one approved for ATTR-CM (and ATTR-PN) is vutrisiran.