Key points:
• Tirzepatide should not be used if you or a family member have Multiple Endocrine Neoplasia type 2 (MEN2) or medullary thyroid carcinoma (MTC). Report any neck lump, hoarseness, trouble swallowing, or shortness of breath.
• Use caution and seek urgent advice for severe abdominal pain, persistent vomiting, jaundice, or signs of dehydration (risk of pancreatitis and gallbladder issues).
• Oral contraceptives may be less effective when starting or increasing dose; use non‑oral contraception or add barrier protection for 4 weeks after initiation and 4 weeks after each dose increase.
• Treatment should be combined with dietary changes and physical activity and monitored regularly per NHS guidance.