Genetics for the People Personalized Histamine Report

  • Histamine Intolerance (HIT) / Mast Cell Activation Syndrome (MCAS) Assessment and Genomic Report

  • This questionnaire is meant to help you better understand whether your symptoms may follow patterns that are often seen in histamine intolerance (HIT) or mast cell activation syndrome (MCAS). It is not a diagnostic tool, and it cannot tell you whether you do or do not have a medical condition.

    Instead, it provides an educational overview of potential risk patterns and areas that may be helpful to explore further. Many of these symptoms can have multiple causes, and only a qualified healthcare professional can evaluate them in the context of your full medical history.

    Your results are intended to support awareness and informed conversations, not to replace medical care or diagnosis.

    The assessment will refer to histamine-related foods. These can be foods that contain histamine, release histamine, or inactivate DAO, the enzyme that breaks down histamine in the intestines. This is not a complete list and varies by individual.

     


    High Histamine Foods

    Alcohol
    Pickled or canned foods (sauerkraut)
    Matured cheeses
    Smoked meats (salami, ham, sausages)
    Shellfish
    Beans and pulses (chickpeas, soybeans, peanuts)
    Nuts (walnuts, cashews)
    Chocolate and cocoa products
    Most citrus fruits
    Wheat-based products
    Vinegar
    Ready meals
    Salty snacks, sweets with preservatives and artificial colorings

     

    Foods That Release Histamine

    Most citrus fruits (kiwi, lemon, lime, pineapple, plums)
    Cocoa and chocolate
    Nuts
    Papaya
    Beans and pulses
    Tomatoes
    Wheat germ
    Additives (benzoate, sulphites, nitrites, glutamate, food dyes)

     

    Foods That Block DAO

    Alcohol
    Black tea
    Energy drinks
    Green tea
    Mate tea

  • Histamine Intolerance (HIT)/ Mast Cell Activation Syndrome (MCAS) Assessment

    The assessment is 111 questions. At the end of the assessment, you will be asked to upload your raw DNA as a .txt file. Please make sure you have enough time to complete all questions and have your raw DNA downloaded before proceeding with the assessment.
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  • 1. Do you experience flushing, especially in the face, neck, and chest, especially after consuming histamine-related foods?*
  • 2. Do you experience itching without a rash, especially after consuming histamine-related foods?*
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  • 3. Do you experience hives (urticaria), especially after consuming histamine-related foods?*
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  • 4. Do you experience dermatographia, especially after consuming histamine-related foods?*
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  • 5. Do you experience eczema flares, especially after consuming histamine-related foods?*
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  • 6. Do you experience swelling (angioedema), especially in the lips, eyes, and/or hands, especially after consuming histamine-related foods?*
  • 7. Do you experience a burning skin sensation, especially after consuming histamine- related foods?*
  • 8. Do you experience temperature instability (hot/cold episodes)?*
  • 9. Do you experience excessive sweating, especially after consuming histamine-related foods?*
  • 10. Do you experience rosacea flares, especially after consuming histamine-related foods?*
  • 11. Do you experience post-meal bloating, especially after consuming histamine-related foods?*
  • 12. Do you experience acid reflux/ GERD?*
  • 13. Do you experience diarrhea after meals, especially after consuming histamine-related foods?*
  • 14. Do you experience nausea, especially after consuming histamine-related foods?*
  • 15. Do you experience cramping abdominal pain, especially after consuming histamine-related foods?*
  • 16. Do you get full fast when eating?*
  • 17. Do you experience IBS-like alternating constipation/diarrhea, especially after eating histamine- related foods?*
  • 18. Do you experience gas, especially after eating histamine-related foods?*
  • 19. Do you experience “stomach burning”, but you don't have an ulcer?*
  • 20. Do you experience gastrointestinal dysmotility symptoms (slow or rapid emptying)?*
  • 21. Do you experience rapid heart rate after eating, especially after eating histamine-related foods?*
  • 22. Do you experience POTS-like symptoms, especially after eating histamine-related foods?*
  • 23. Do you experience blood pressure drops, positional or after meals, especially after eating histamine-related foods?*
  • 24. Do you experience heart palpitations, especially after eating histamine-related foods?*
  • 25. Do you experience chest tightness that is not related to your heart, especially after eating histamine- related foods?*
  • 26. Do you experience nasal congestion without infection, especially after eating histamine-related foods?*
  • 27. Do you experience sneezing fits, especially after eating histamine-related foods?*
  • 28. Do you experience asthma-like wheezing, especially after eating histamine-related foods?*
  • 29. Do you experience shortness of breath that comes and goes?*
  • 30. Do you experience throat tightness (globus sensation)?*
  • 31. Do you experience dry cough, especially after eating histamine-related foods?*
  • 32. Do you experience headaches, especially pressure-type, or migraines, especially after eating histamine-related foods?*
  • 33. Do you experience brain fog, especially after eating histamine-related foods?*
  • 34. Do you experience dizziness / lightheadedness, especially after eating histamine-related foods?*
  • 35. Do you experience sensory overload (light, sound, smell), especially after eating histamine-related foods?*
  • 36. Do you experience anxiety or panic episodes, especially after eating histamine-related foods?*
  • 37. Do you have trouble concentrating?*
  • 38. Do you experience tingling on your skin that doesn't stay in the same spot all the time?*
  • 39. Do you experience bladder irritation, like you have a urinary tract infection (UTI) but test negative for a UTI (Interstitial Cystitis-like)?*
  • 40. Do you experience frequent urination?*
  • 41. Women: Do you experience pelvic pain flares?*
  • 42. Women: Do you experience pain during ovulation/period flares?*
  • 43. Women: Do you experience worsening symptoms around ovulation/period?*
  • 44. Do you experience hypoglycemia-like feelings without low glucose?*
  • 45. Do you experience reactions to alcohol, especially wine, beer?*
  • 46. Do you experience reactions to fragrances and/ or chemicals?*
  • 47. Do you experience delayed reactions, 4–24 hours after triggers?*
  • 48. Do you experience chronic fatigue?*
  • 49. Do you experience frequent “allergic” symptoms with normal tests?*
  • 50. Do you experience joint pain / stiffness?*
  • 51. Do you experience muscle pain?*
  • 52. Do you experience bone pain?*
  • 53. Do you experience exercise intolerance?*
  • 54. Do you experience insomnia, especially after eating histamine-related foods?*
  • 55. Do you experience wake up at night with a racing heart, especially after eating histamine-related foods?*
  • 56. Do you experience vivid dreams or nightmares, especially after eating histamine-related foods?*
  • 57. When you eat leftover meat or fish (even properly stored), do you react more severely than when eating the same food freshly cooked?*
  • 58. Have you tried over-the-counter DAO enzyme supplements (e.g., UmbrelluxDAO, Histamine Digest) before meals? If so, what was the effect?*
  • 59. Does alcohol, especially red wine, champagne, or beer, cause disproportionately severe symptoms compared to a small amount of spirits like vodka?*
  • 60. Did your symptoms get better or worse after a course of antibiotics, a food poisoning episode, or a gastrointestinal infection?*
  • 61. Have you tried Zinc Carnosine or Deglycyrrhizinated Licorice (DGL)? What was the effect on your gut symptoms?*
  • 62. Have you tried probiotics (especially Lactobacillus-based)? Do they make bloating, brain fog worse or better?*
  • 63. Have you ever tried a methylated B-complex, methylfolate, or SAM-e? Did it make you feel better, worse (e.g., anxious, irritable, insomnia), or no change?*
  • 64. Do anxiety, panic, or racing thoughts begin 30-90 minutes AFTER eating a high-histamine meal?*
  • 65. Do you have a strong reaction to sulfites (in dried fruit, wine, some medications) or foods high in natural sulfur (eggs, cruciferous veggies, garlic)?*
  • 66. Do you feel better or worse after sweating (e.g., exercise, sauna), not just getting hot?*
  • 67. Have you tried high-dose Vitamin C (ascorbic acid or liposomal)? What was the effect?*
  • 68. Do you react to non-ingestion triggers like strong smells (perfumes, chemicals), temperature changes, stress, or friction on your skin?*
  • 69. Have you tried over-the-counter H1 antihistamines (e.g., fexofenadine, cetirizine) or H2 blockers (e.g., famotidine) regularly? How effective are they?*
  • 70. Have you tried supplements like Quercetin, Luteolin, or Ketotifen (if available)? What was the effect?*
  • 71. Do you have multiple diagnosed chemical or drug sensitivities?*
  • 72. Do your reactions sometimes occur hours after exposure to a trigger, making it hard to identify?*
  • 73. Is your bloating predominantly in the lower abdomen and does it tend to worsen as the day goes on, regardless of food?*
  • 74. Have you ever been tested or treated for SIBO? If treated, did your histamine symptoms improve (even temporarily)?*
  • 75. Do high-fiber foods, prebiotics (like inulin), or resistant starch significantly worsen your symptoms?*
  • 76. Do you experience sulfur-smelling gas?*
  • 77. Does following a strict low-FODMAP diet significantly reduce your symptoms?*
  • 78. Can simply thinking about a stressful event or a food you're afraid of trigger physical sensations?*
  • 79. Have you tried vagus nerve stimulation techniques (e.g., humming, deep diaphragmatic breathing, cold exposure)? Any benefit?*
  • 80. Do you have a history of significant trauma, illness, or stress that preceded the onset of your symptoms?*
  • 81. Do you experience worsening symptoms after consuming food containing monosodium glutamate (MSG) or MSG-like compounds?*
  • 82. Do you have a positive Beighton Score (5 or more for adults, 6 or more for children)? You can find the Beighton test here: Beighton-Score-2017.pdf*
  • 83. Do you wake up with 'morning anxiety' or a racing heart for no apparent reason?*
  • 84. Do you feel a sudden wave of anxiety or doom that is then followed within minutes by physical symptoms?*
  • 85. Do you have unusually soft or velvety skin?*
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  • 86. Do you have stretchy skin?*
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  • 87. Do you have unexplained striae (stretch marks) not from pregnancy/ weight changes?*
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  • 88. Do you have bilateral piezogenic papules of heels?*
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  • 89. Do you have atrophic scarring (papyraceous/cigarette paper scars)?*
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  • 90. Do you have arachnodactyly (long slender fingers)?*
  • 91. Have you been told you have mitral valve prolapse in your heart (on echo)?*
  • 92. Have you been told you have aortic root dilatation (Z-score >+2)?*
  • 93. Have you been told you have recurrent or multiple abdominal hernia(s)?*
  • 94. Have you been told or know you have pelvic floor, rectal, or uterine prolapse?*
  • 95. Have you been told or know you have dental crowding and high/narrow palate?*
  • 96. Do any of your first degree relatives have an Ehlers-Danlos Syndrome diagnosis? (Mother, Father, Siblings, Children)?*
  • 97. Do you have chronic, widespread pain (lasting for greater than or equal to 3 months)?*
  • 98. Do you have recurrent joint disloactions (subluxations)?*
  • 99. What was the state of your health before your current histamine symptoms began? Were you generally healthy, or did you have minor issues?*
  • 100. Did your histamine symptoms begin suddenly or gradually? If sudden, can you tie it to a specific event, such as: A severe flu-like illness? A case of suspected or confirmed COVID-19? A case of infectious mononucleosis (mono)? Another significant infection (e.g., severe gastroenteritis, pneumonia)?*
  • 101. If your symptoms began after an infection, did they:*
  • 102. Prior to your symptom onset, did you experience a period of unusually high stress, poor sleep, or emotional trauma?*
  • 103. Do your symptoms flare in a cyclical or "waxing and waning" pattern (e.g., feeling better for a few days, then crashing for a week), seemingly without a clear trigger?*
  • 104. Do you experience frequent or recurring sore throats, swollen lymph nodes (especially in the neck), or low-grade fevers (e.g., 99.0-99.5°F / 37.2-37.5°C) that come and go?*
  • 105. Do you have any persistent nerve-related sensations (e.g., burning, tingling, "electric shock" feelings, numbness) that move around your body?*
  • 106. Have you been diagnosed with or suspect you have Postural Orthostatic Tachycardia Syndrome (POTS), Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), or Fibromyalgia since your symptoms began?*
  • 107. Have you ever been diagnosed with mononucleosis (mono), Epstein-Barr Virus (EBV), Cytomegalovirus (CMV), or Shingles (Herpes Zoster)?*
  • 108. If you get frequent cold sores (oral herpes/HSV-1) or genital herpes outbreaks, has the frequency or severity of these changed since your overall symptoms began?*
  • 109. Have you had your antibody titers checked for viruses like EBV (VCA IgG/IgM, EA, EBNA), CMV, or HHV-6? If so, what were the results? (Do not include results for HIV)*
  • 110. Have you had basic immune labs done? If so, were any of the following persistently abnormal: *High or low white blood cell count? *High or low lymphocyte count? *Low IgA, IgG, or IgM? *High inflammatory markers (CRP, ESR, cytokines like IL-6)?*
  • 111. Do you catch every virus that "goes around" and take longer than others to recover from simple colds?*

  • Raw DNA File Upload

  • We can currently process AncestryDNA, 23andMe, and Sequencing.com raw DNA text files. If you have your DNA sequenced via another service, just shoot us an email and we will be happy to make sure it is compatible with our system.

    If you have whole-genome sequencing data from sequencing.com, we can run your full genome files to gather you additional data, for the same cost. Please email us to let us know you'd like your full data read and the next steps in that process.

    If you need help downloading your raw DNA data, please follow the links below:

    AncestryDNA

    23andMe

    Sequencing.com (Ultimate Compatibility File)


    You can list any name you would like on the report. Please be aware that we cannot determine which raw DNA file belongs to which person, so please make sure to record any aliases you use. 

    We will email your Personalized Histamine Report to the email provided within 5 business days. Most of the time, it is sent within 24 hours.

    If you do not recieve your Histamine Report within 5 business days, please check your spam folder for an email from us. Your raw DNA file may be corrupted and need resubmission.

    If you have any questions or concerns, please email us at GeneticsforthePeople@gmail.com.

     

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