PET-tle Royale 2026

The first edition of HAI was held in:* This field is required.

Miami

Boston

San Juan

San Diego

T/F: Centiloid values are always between 0 and 100

True

False

In session 1, which of Renaud's fruits was most dodgy?

Banana 🍌

Pineapple 🍍

Coconuts 🥥

Peach 🍑

Eggplant 🍆

Which is the earliest name for Flortaucipir:

AV-1451

T-807

AV-45

Florzolotau

CSF or Plasma p-tau217 is most correlated with:

Tau PET

Amyloid PET

Neurodegeneration

From session 2, among tau PET harmonization schemes:

CenTauR is linear and Unitau is nonlinear

CenTauR is nonlinear and Unitau is linear

Both schemes are linear

Both schemes are nonlinear

Which ATN stage is shown below?Answer on the next page

Which ATN stage is shown on the previous card?

A-T-(N)-

A+T-(N)-

A+T+(N)-

A+T+(N)+

Type a question

AV-1451

NAV4694

MK-6240

GTP-1

PI-2620

RO-948

The figure shown below depicts

Answer on the next page

The figure shown on the previous card depicts

Braak staging

ATN Staging

Jack curves

Thal staging

Alois Alzheimer wrote his doctoral thesis on:

Auguste Deter

The structure of amyloid plaques

Epilepsy

Earwax

In the Alzheimer's Association AD criteria, FDG PET is a marker of:

Amyloid

Tau

Neurodegeneration

Vascular disease

ARIA stands for:

Alzheimer's-Related Imaging Anomaly

Amyloid-Related Imaging Abnormality

Amyloid-Related Inflammation at Autopsy

Alzheimer's-Related Inflammation Abnormality

Which is not a stage of tau tangles?

pre-tangles

young tangles

mature tangles

ghost tangles

Which is a common acquisition time window for PIB PET:

50-70 minutes post-injection

80-120 minutes post-injection

60-90 minutes post-injection

70-90 minutes post-injection

The amyloid PET scan below should be read as:

Answer on the next page

The amyloid PET scan shown on the previous card should be read as:

Positive

Negative

unreadable: corrupted by motion

A mislabeled tau PET scan

Which is a common region of off-target binding for MK-6240?

Basal ganglia

Meninges

Choroid plexus

White matter

Which is a common region of off-target binding for Flortaucipir?

meninges

cerebellum

supratentorial white matter

basal ganglia

Which protein has been the scourge of all tau and a-syn tracers, most often blamed for off-target binding?

TSPO

MAO-A

MAO-B

TDP-43

NfL

Plasma GFAP is used as a measure of:

Neuroinflammation

Tau

Neurodegeneration

Amyloid

89M with progressive amnestic dementia. Most likely DX?

Answer on the next page

89M with progressive amnestic dementia. Most likely DX?

TDP43/LATE

Vascular dementia

DLB

This meeting has largely agreed that PET-based Braak ROIs:

Accurately reflect Braak staging at autopsy

Are consistently more sensitive and higher than Braak staging at autopsy

Are consistently less sensitive and lower than Braak staging at autopsy

This focal FTP signal surrounding a hypointense area was caused by:

(Answer on the next page)

This focal FTP signal surrounding a hypointense area was caused by:

Off-target binding related to TDP-43

On-target binding to AD-related tau

Off-target binding related to a cortical infarct

Motion / attenuation correction artifact

In May 2025, the FDA approved the first plasma marker for detection of amyloid plaques, based on:

Aβ42/40

pTau217

pTau217/Aβ42

pTau181

Approved anti-amyloid therapeutics typically have what effect on MRI gray matter volume and cortical thickness?

Increase

Decrease

No change

Increase gray matter volume but reduce cortical thickness

Which ATN stage is shown below?

Answer on the next page

Which ATN stage is shown on the previous card?

A-T-(N)-

A+T-(N)-

A+T+(N)-

A+T+(N)+

The primary purpose of the CT scan in PET-CT is to help correct for:

Motion

Signal attenuation

Partial volume effects

Head size / TIV

Autoradiography is a process to measure:

spatial autocorrelation of PET scans

correlation over time in dynamic scans

tracer binding in tissue samples

point spread function / scanner resolution

In the keynote, which network architecture was considered the most recent and most advanced?

GAN

LAN

Transformer

U-Net

CNN

Decepticon

An abnormal CSF or plasma AB42/40 level associated with amyloid plaques is:

abnormally high

abnormally low

in a mid-range, neither abnormally high or low

AB42/40 is actually a nonspecific marker of neurodegeneration

Which is true of Flortaucipir in-vivo in non-AD pathologies, at the group level

Binds strongly in GM to all tauopathies

Weakly elevated in GM for non-AD tauopathies only

Weakly elevated in juxtacortical WM for both 4-R tau and TDP-43

Weakly elevated in juxtacortical WM for 4-R tau but not TDP-43