Common side effects may include nausea, vomiting, diarrhea, constipation, abdominal discomfort, reflux, fatigue, headache, and decreased appetite. Most side effects are temporary and may improve with dose adjustment or time.
More serious but uncommon risks may include pancreatitis, gallbladder disease, kidney injury, severe gastrointestinal complications, allergic reaction, or thyroid tumors in predisposed individuals. Individuals with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2) are not appropriate candidates for GLP-1 receptor agonist therapy.
Patients agree to promptly report severe abdominal pain, persistent vomiting, signs of dehydration, allergic reaction, or any concerning symptoms to their provider.