PEPWISE Registry — Baseline Intake

  • Informed Consent

    Please review the information below before continuing.

  • Your Compound Use

  • This section asks about the peptides or bioactive compounds you are currently using or plan to start using.
  • Which compound(s) are you currently using or plan to start? (Select all that apply)*
  • Route of administration for primary compound?
  • How often do you take your primary compound?
  • How long have you been using your primary compound?*
  • Where do you obtain your primary compound?

  • Your Health and Well-Being (PROMIS-29)

  • The following questions ask about your health and well-being over the PAST 7 DAYS. Please answer each question as honestly as you can. There are no right or wrong answers.

  • Physical Function

  • Are you able to do chores such as vacuuming or yard work?*
  • Are you able to go up and down stairs at a normal pace?*
  • Are you able to go for a walk of at least 15 minutes?*
  • Are you able to run errands and shop?*

  • Anxiety

  • In the past 7 days, I felt fearful.*
  • In the past 7 days, I found it hard to focus on anything other than my anxiety.*
  • In the past 7 days, my worries overwhelmed me.*
  • In the past 7 days, I felt uneasy.*

  • Depression

  • In the past 7 days, I felt worthless.*
  • In the past 7 days, I felt helpless.*
  • In the past 7 days, I felt depressed.*
  • In the past 7 days, I felt hopeless.*

  • Fatigue

  • In the past 7 days, I felt fatigued.*
  • In the past 7 days, I had trouble starting things because I was tired.*
  • In the past 7 days, how run-down did you feel on average?*
  • In the past 7 days, how fatigued were you on average?*
  • PEPWISE (Peptide Wellness Insight and Self-Reported Experience) Registry is a prospective observational registry operated by MeLi MeThoDS, LLC. PURPOSE: PEPWISE collects self-reported wellness data from adults who are already using peptide compounds. We use the NIH-validated PROMIS-29 instrument to track how you feel over 90 days. This is NOT a clinical trial. We do not prescribe, supply, or recommend any compounds. WHAT PARTICIPATION INVOLVES: You will complete this baseline questionnaire (15-20 minutes). If you have been using your compounds for 30 or more days, you may also complete a retrospective follow-up section today. You will receive a 30-day and/or 90-day follow-up by email. RISKS: Minimal. The primary risk is a potential breach of confidentiality, which we mitigate through de-identification. This registry does not involve any medical procedures or changes to your regimen. PRIVACY: Your responses are assigned a random participant ID (PW-XXXX). We do NOT collect your name, date of birth, or Social Security number. Data is stored on HIPAA-compliant servers with 256-bit encryption. De-identified data may be used in aggregate analyses or regulatory comments. Individual responses are never shared. Data retained for 7 years. VOLUNTARY: You may skip any question or withdraw at any time. To withdraw, email pepwise@melimethods.com with your participant ID. REGULATORY STATUS: This registry qualifies for exemption from IRB review under 45 CFR 46.104(d)(2). Formal acknowledgment from Advarra IRB is pending. CONTACT: Melissa Mena-Schneller, MS, MeLi MeThoDS, LLC — pepwise@melimethods.com If you are experiencing a medical emergency, call 911.
  • Do you consent to participate in the PEPWISE Registry?*
  • I confirm that I am 18 years of age or older*

  • About You

  • What is your biological sex?*
  • What is your gender identity?
  • What is your ethnicity?
  • What is your race? (Select all that apply)

  • Health Background

  • Have you been diagnosed with any of the following conditions? (Select all that apply)
  • Do you have any known allergies to medications or supplements?
  • Have you had any surgeries in the past 5 years?

  • Primary Health Complaint

  • Sleep Disturbance

  • In the past 7 days, my sleep quality was...*
  • In the past 7 days, my sleep was refreshing.*
  • In the past 7 days, I had a problem with my sleep.*
  • In the past 7 days, I had difficulty falling asleep.*

  • Ability to Participate in Social Roles

  • I have trouble doing all of my regular leisure activities with others.*
  • I have trouble doing all of the family activities that I want to do.*
  • I have trouble doing all of my usual work (include work at home).*
  • I have trouble doing all of the activities with friends that I want to do.*

  • Pain Interference

  • In the past 7 days, how much did pain interfere with your day-to-day activities?*
  • In the past 7 days, how much did pain interfere with work around the home?*
  • In the past 7 days, how much did pain interfere with your ability to participate in social activities?*
  • In the past 7 days, how much did pain interfere with your household chores?*

  • Pain Intensity

  • Felt Effects

  • Since starting your peptide(s), have you noticed any of the following POSITIVE effects? (Select all that apply)
  • Have you noticed any NEGATIVE effects or side effects? (Select all that apply)
  • Overall, how would you describe your experience with peptides so far?*

  • 30-Day Check-In

    If you have been using any of your peptides for 30 days or more, please complete this section. If not, skip ahead to the final page.
  • Have you been using any of your selected peptides for 30 days or more?*
  • Over the past 30 days, how consistently have you used your peptide(s) as intended?
  • Have you experienced any adverse events or side effects that concerned you in the past 30 days?
  • Compared to when you STARTED using peptides, how would you rate your primary health concern now?
  • Compared to when you started, how would you rate your overall quality of life?

  • 90-Day Check-In

    If you have been using any of your peptides for 90 days or more, please complete this section. If not, skip ahead to submit.
  • Have you been using any of your selected peptides for 90 days or more?*
  • Since you began using peptides, how much has your overall condition changed?
  • Overall, how satisfied are you with your peptide experience?
  • Would you recommend peptide use to others with similar health concerns?
  • How valuable has participating in this registry been to you?
  • Would you be willing to participate in a brief follow-up interview (15-20 minutes, via Zoom)?
  • Should be Empty: