Black box warning summary: Prescription weight loss injections may carry serious risks and side effects, including potential severe gastrointestinal symptoms (such as nausea, vomiting, diarrhea, and abdominal pain), dehydration, acute kidney injury, gallbladder disease, pancreatitis, and possible worsening of diabetic retinopathy. In some patients, these medications may also increase the risk of thyroid C-cell tumors; they should not be used in people with a personal or family history of medullary thyroid carcinoma or MEN2. These medications may also delay gastric emptying, which can affect tolerance of food and oral medications, and may contribute to hypoglycemia when used with other glucose-lowering drugs. Review all risks, warnings, benefits, and precautions with a qualified clinician before starting treatment.