The following research question formats are structured to help you think clearly about the patient population, specific intervention, comparator groups, and the outcomes the SER will address. Here are a few examples:
1. In patients with non-small cell lung cancer on maintenance treatment (P), is liquid biopsy (I) more accurate to diagnose relapse (O) than standard of care imaging and/or biopsy (C)?
2. In patients without a family history of colorectal cancer (P), how does use of population screening for genetic risk variants with a genotyping panel or whole exome sequencing (I) influence their adherence to standard colorectal screening recommendations (O) compared to patients who do not receive genetic screening (C)?
3. In patients up to ten years old with a clinical diagnosis of autism spectrum disorder (P), what is the effect of genetic testing (I) within two years of diagnosis (T) on reproductive decision-making of the parents (O) compared with patients who do not receive genetic testing (C)?