Sorry, the correct answer is B - Diarrhea. Patients with myeloproliferative neoplasms (MPNs) often suffer from debilitating constitutional symptoms that negatively impact quality of life. The most common symptoms recently reported in a 2022 article by Tremblay, et al. included fatigue (reported in 81%), pruritis (52%), night sweats (49%), bone pain (44%), fevers (14%), and unintended weight loss (13%). Symptom burden was highest in patients with myelofibrosis and can affect quality of life in a manner similar to patients with metastatic solid tumors.